Health Hazard Information of ethylbenzene

Acute Effects:

Respiratory effects, such as throat irritation and chest constriction, irritation of the eyes, and neurological effects such as dizziness, have been noted from acute inhalation exposure to ethylbenzene in humans.

Animal studies have reported central nervous system (CNS) toxicity; pulmonary effects; and effects on the liver, kidney, and eyes (irritation) from acute inhalation exposure to ethylbenzene.

Tests involving acute exposure of rats have shown ethylbenzene to have moderate toxicity from inhalation and oral exposure.

Chronic Effects (Noncancer):

Chronic exposure to ethylbenzene by inhalation in humans has shown conflicting results regarding its effects on the blood.  In one study of workers occupationally exposed to ethylbenzene, effects on the blood were noted, while in another study, no adverse effects on the blood were seen.

In a 20-year study of humans occupationally exposed to ethylbenzene, no liver toxicity was noted.

Animal studies have reported effects on the blood, liver, and kidneys from chronic inhalation exposure to ethylbenzene.

The Reference Concentration (RfC) for ethylbenzene is 1 milligram per cubic meter (mg/m3) based on developmental toxicity in rats and rabbits. The RfC is an estimate (with uncertainty spanning perhaps an order of magnitude) of a continuous inhalation exposure to the human population (including sensitive subgroups), that is likely to be without appreciable risk of deleterious noncancer effects during a lifetime. It is not a direct estimator of risk but rather a reference point to gauge the potential effects. At exposures increasingly greater than the RfC, the potential for adverse health effects increases. Lifetime exposure above the RfC does not imply that an adverse health effect would necessarily occur.

EPA has low confidence in the study on which the RfC was based because higher exposure levels may have provided more information on the potential for maternal toxicity and developmental effects; low confidence in the database because, although other studies have examined a variety of other endpoints (e.g., liver and lung), by histopathology in rats and mice, there are no chronic studies and no multigeneration developmental studies; and, consequently, low confidence in the RfC.

The Reference Dose (RfD) for ethylbenzene is 0.1 milligrams per kilogram body weight per day (mg/kg/d) based on liver and kidney toxicity in rats.

EPA has low confidence in the study on which the RfD was based because rats of only one sex were tested and the experiment was not of chronic duration; low confidence in the supporting database because other oral toxicity data were not found; and, consequently, low confidence in the RfD

Reproductive/Developmental Effects:

No information is available on the developmental or reproductive effects of

ethylbenzene in humans.

Animal studies have reported developmental effects, such as fetal resorptions, retardation of skeletal development, and an increased incidence of extra ribs in animals exposed to ethylbenzene via inhalation.

Cancer Risk:

The only available human cancer study monitored the conditions of workers exposed to ethylbenzene for 10 years, with no tumors reported. However, no firm conclusions can be made from this study because exposure information was not provided, and 10 years is insufficient for detecting long latency tumors in humans.

In a study by the NTP, exposure to ethylbenzene by inhalation resulted in a clearly increased incidence of kidney and testicular tumors in male rats, and a suggestive increase in kidney tumors in female rats, lung tumors in male mice, and liver tumors in female mice.

EPA has classified ethylbenzene as a Group D, not classifiable as to human carcinogenicity.